MPTP

From Fresh Dictionary

English

Initialism

MPTP

1. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
2. A byproduct of synthetic heroin, or MPPP, which causes Parkinsonian symptoms in users
3. A neurotoxin which degrades into MPP+ after crossing the blood brain barrier, which causes a degredation of the dopaminergic neurons within the substantia nigra

Quotations

• 2005 Dec 29 Petzinger, et al. Journal of Neuroscience Research [1]

  The neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP provides an excellent opportunity to study repair and response to injury in the basal ganglia.